Hematological Risk Factors for Coronary Heart Disease | Zendy

M.A.F. ElHazmi | Zendy

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Hematological Risk Factors for Coronary Heart Disease

Author(s) -

M.A.F. ElHazmi

Publication year - 2002

Publication title -

medical principles and practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.426

H-Index - 45

eISSN - 1423-0151

pISSN - 1011-7571

DOI - 10.1159/000066407

Subject(s) - medicine , antithrombin , etiology , plasminogen activator , risk factor , protein c , disease , factor v leiden , heart disease , thrombosis , gene mutation , cardiology , venous thrombosis , mutation , gene , genetics , heparin , biology

Coronary heart disease (CHD) is a leading cause of morbidity and mortality in the developed and developing countries. Several underlying genetic and environmental factors have been implicated in its etiology. Some of the hematological risk factors implicated in the development of coronary heart disease include antithrombin III deficiency, protein C and protein S deficiency, factor V Leiden mutation, prothrombin gene (20210A) mutation hyperhomocystinaemia, elevated factor VIII levels, plasminogen activator inhibitor type 1 and dysfibrinogenaemia. In general, these factors result in thrombosis, thus having a negative effect on the heart and blood vessels. This paper presents an overview of some of the hematological risk factors involved in the development of CHD.

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