Hyperuricemia Causes Glomerular Hypertrophy in the Rat | Zendy

Takahiko Nakagawa | Zendy; Marilda Mazzali | Zendy; DukHee Kang | Zendy; John Kanellis | Zendy; Susumu Watanabe | Zendy; Laura Gabriela SánchezLozada | Zendy; Bernardo RodríguezIturbe | Zendy; Jaime Herrera-Acosta | Zendy; Richard J. Johnson | Zendy

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Hyperuricemia Causes Glomerular Hypertrophy in the Rat

Author(s) -

Takahiko Nakagawa,

Marilda Mazzali,

DukHee Kang,

John Kanellis,

Susumu Watanabe,

Laura Gabriela SánchezLozada,

Bernardo RodríguezIturbe,

Jaime Herrera-Acosta,

Richard J. Johnson

Publication year - 2002

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000066303

Subject(s) - hyperuricemia , medicine , glomerulosclerosis , endocrinology , febuxostat , enalapril , allopurinol , muscle hypertrophy , hydrochlorothiazide , afferent arterioles , renal hypertrophy , uric acid , nephropathy , microalbuminuria , kidney , renal function , blood pressure , angiotensin ii , proteinuria , angiotensin converting enzyme , diabetic nephropathy , diabetes mellitus

Rats with mild hyperuricemia develop systemic hypertension, interstitial renal disease, afferent arteriolopathy, and increased renin expression [Mazzali et al.: Am J Physiol 2002;6:F991-F997]. We hypothesized that hyperuricemia might also induce glomerular changes.

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