Nephrotic-Like Proteinuria in Experimental Diabetes | Zendy

Kerryn A Greive | Zendy; Tanya M. Osicka | Zendy; Leileata M. Russo | Zendy; Wayne D. Comper | Zendy

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Nephrotic-Like Proteinuria in Experimental Diabetes

Author(s) -

Kerryn A Greive,

Tanya M. Osicka,

Leileata M. Russo,

Wayne D. Comper

Publication year - 2002

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000066297

Subject(s) - endocrinology , medicine , excretion , proteinuria , albuminuria , albumin , blood proteins , radioimmunoassay , streptozotocin , orosomucoid , transferrin , diabetes mellitus , chemistry , kidney , biochemistry , glycoprotein

Streptozotocin (STZ) diabetic rats are characterized by the development of albuminuria. It is not known, however, whether the excess excretion of protein is primarily due to intact protein or protein fragments or whether it is specific for albumin or occurs for all high-molecular-weight plasma proteins. To test this we have measured the excretion rates and fractional clearances of [(14)C]albumin, [(3)H]immunoglobulin G and [(3)H]transferrin in diabetic rats.

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