Serum Matrix Metalloproteinases MMP-2 and MMP-3 Levels in Dialysis Patients Vary Independently of CRP and IL-6 Levels | Zendy

Gloria A. Preston | Zendy; Cheri Barrett | Zendy; David A. Alcorta | Zendy; Susan L. Hogan | Zendy; Lesley C. Dinwiddie | Zendy; J. Charles Jennette | Zendy; Ronald J. Falk | Zendy

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Serum Matrix Metalloproteinases MMP-2 and MMP-3 Levels in Dialysis Patients Vary Independently of CRP and IL-6 Levels

Author(s) -

Gloria A. Preston,

Cheri Barrett,

David A. Alcorta,

Susan L. Hogan,

Lesley C. Dinwiddie,

J. Charles Jennette,

Ronald J. Falk

Publication year - 2002

Publication title -

the nephron journals/nephron journals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.951

H-Index - 72

eISSN - 2235-3186

pISSN - 1660-8151

DOI - 10.1159/000065464

Subject(s) - medicine , hemodialysis , dialysis , peritoneal dialysis , matrix metalloproteinase , gastroenterology , c reactive protein , end stage renal disease , inflammation , kidney disease , interleukin 6 , immunology

Patients on chronic hemodialysis or peritoneal dialysis often develop an inflammatory state that causes morbidity and mortality. Cross-sectional studies of dialysis patients have determined that C-reactive protein (CRP) is a predictor of morbidity. Little is known as to whether CRP, cytokines, such as IL-6 and IL-1beta that stimulate the synthesis of CRP, or matrix metalloproteinases (MMPs) are markers of inflammation in patients on dialysis.

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