Open AccessCommon C677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene and the Risk of Venous Thromboembolism: Meta-Analysis of 31 Studies
Author(s) -
Joel G. Ray,
Doron Shmorgun,
WeeShian Chan
Publication year - 2002
Publication title -
pathophysiology of haemostasis and thrombosis
Language(s) - English
Resource type - Journals
eISSN - 1424-8840
pISSN - 1424-8832
DOI - 10.1159/000065076
Subject(s) - methylenetetrahydrofolate reductase , odds ratio , hyperhomocysteinemia , medicine , genotype , gastroenterology , confidence interval , thrombophilia , meta analysis , homocysteine , factor v leiden , venous thrombosis , thrombosis , genetics , gene , biology
Although the common 677 C --> T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene is implicated in the development of hyperhomocysteinemia, its correlation with venous thromboembolism (VTE) remains controversial. We conducted a meta-analysis of previously published studies to clarify the role of the MTHFR 677 TT homozygous genotype in association with VTE.
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