Recognition of Resveratrol by the Human Estrogen Receptor-Alpha: A Molecular Modeling Approach to Understand Its Biological Actions | Zendy

Abdalla M. ElMowafy | Zendy; Laila AbouZeid | Zendy; Ivan O. Edafiogho | Zendy

Open Access

Recognition of Resveratrol by the Human Estrogen Receptor-Alpha: A Molecular Modeling Approach to Understand Its Biological Actions

Author(s) -

Abdalla M. ElMowafy,

Laila AbouZeid,

Ivan O. Edafiogho

Publication year - 2002

Publication title -

medical principles and practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.426

H-Index - 45

eISSN - 1423-0151

pISSN - 1011-7571

DOI - 10.1159/000058013

Subject(s) - estrogen receptor alpha , alpha (finance) , estrogen receptor , resveratrol , estrogen receptor beta , estrogen , receptor , agonist , diethylstilbestrol , binding site , molecular model , stereochemistry , chemistry , biochemistry , medicine , endocrinology , construct validity , nursing , cancer , breast cancer , patient satisfaction

Resveratrol (RSVL) is an edible phytoestrogen with multifaceted health benefits that may originate from binding to the estrogen receptors. Despite its structural similarity to the estrogen receptor-alpha (ER alpha) agonist diethylstilbestrol (DES), RSVL showed distinct biological profiles in estrogen-responsive biological systems. The molecular basis of such biological profiles has been undefined.

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