The Potential Role of Apoptosis in Human Disease | Zendy

Bengt Fadeel | Zendy; Sten Orrenius | Zendy; Boris Zhivotovsky | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The Potential Role of Apoptosis in Human Disease

Author(s) -

Bengt Fadeel,

Sten Orrenius,

Boris Zhivotovsky

Publication year - 2000

Publication title -

medical principles and practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.426

H-Index - 45

eISSN - 1423-0151

pISSN - 1011-7571

DOI - 10.1159/000054240

Subject(s) - apoptosis , medicine , disease , immune system , programmed cell death , immune dysregulation , pathological , immunology , homeostasis , bioinformatics , cancer research , biology , pathology , genetics

Programmed cell death or apoptosis is an evolutionarily conserved process which is essential for the maintenance of tissue homeostasis. Recent studies have indicated a role for apoptosis in a variety of human diseases. Hence, dysregulation of apoptosis has been implicated in, for instance, systemic and organ-specific autoimmune disease, acquired immune deficiency syndrome, neurodegenerative disorders, atherosclerosis and cancer. This presentation serves as an overview of pathological conditions, which are associated with defective or inadvertent apoptosis, with examples of disorders in which putative apoptosis defects have been elucidated at the molecular level. A critical assessment of apoptosis as a target for therapeutic intervention is also provided.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research