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Cardiovascular mortality is higher in dialysis patients than the nonuremic population. This has been taken to indicate that dialysis patients have accelerated atherosclerosis [1]. We have recently revealed that atherosclerosis in hemodialysis patients is advanced morphologically, showing a greater intima media thickness in the carotid and femoral arteries in dialysis patients than healthy control subjects by high-resolution B mode ultrasonography [2]. Lipoprotein abnormality is one of the major risk factors for atherosclerosis in the general population, and recent studies [3–6] reemphasize the importance of triglyceride-rich lipoproteins such as partially lipolyzed very low density lipoprotein (VLDL) and intermediate density lipoprotein (IDL). These lipoprotein classes are significantly elevated in patients with chronic renal failure [7–9].

the nephron journals/nephron journals

Secondary Hyperparathyroidism, Decreased Hepatic Triglyceride Lipase, Elevated Intermediate Density Lipoprotein and Atherosclerosis in Hemodialysis Patients