The Expression of Water Channels AQP1 and AQP2 in a Large Series of ADPKD Kidneys | Zendy

Olivier Devuyst | Zendy

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The Expression of Water Channels AQP1 and AQP2 in a Large Series of ADPKD Kidneys

Author(s) -

Olivier Devuyst

Publication year - 1997

Publication title -

the nephron journals/nephron journals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.951

H-Index - 72

eISSN - 2235-3186

pISSN - 1660-8151

DOI - 10.1159/000044893

Subject(s) - aquaporin 2 , medicine , duct (anatomy) , cyst , kidney , pathology , urology , water channel , mechanical engineering , engineering , inlet

We read with interest the paper by Hayashi et al. [1] reporting the expression of AQP2 and AQP3 in cyst-lining epithelial cells from ADPKD kidneys. The authors suggest that about 30% of the cysts in ADPKD are derived from collecting-duct cells and that these cells remain well differentiated in terms of AQP expression. However, these conclusions are limited by the small number of ADPKD kidneys (n = 2) studied and by the fact that both AQP2 and AQP3 are located in the same cells – the principal cells of the collecting duct.

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