Cushing’s Disease in a 7-Month-Old Girl due to a Tumor Producing Adrenocorticotropic Hormone and Thyreotropin-Secreting Hormone | Zendy

Julian List | Zendy; Stephan B. Sobottka | Zendy; Angela Huebner | Zendy; C. Bonk | Zendy; J. Koy | Zendy; T. Pinzer | Zendy; Gabriele Schackert | Zendy

Open Access

Cushing’s Disease in a 7-Month-Old Girl due to a Tumor Producing Adrenocorticotropic Hormone and Thyreotropin-Secreting Hormone

Author(s) -

Julian List,

Stephan B. Sobottka,

Angela Huebner,

C. Bonk,

J. Koy,

T. Pinzer,

Gabriele Schackert

Publication year - 1999

Publication title -

pediatric neurosurgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.385

H-Index - 72

eISSN - 1423-0305

pISSN - 1016-2291

DOI - 10.1159/000028824

Subject(s) - adrenocorticotropic hormone , medicine , pituitary adenoma , adenoma , cushing's disease , lesion , pituitary tumors , hormone , endocrinology , cushing disease , anterior pituitary , cushing syndrome , pathology , disease

We present the case of a 7-month-old baby with Cushing's disease due to an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma combined with cells producing thyreotropin-secreting hormone (TSH). In MRI scans, a contrast-enhancing lesion was seen inside the pituitary fossa, and it extended into the suprasellar region. On the assumption of a pituitary adenoma, surgery was performed. Corresponding with biochemical findings, histopathological evaluation revealed an ACTH- and TSH-producing tumor. Genetic analysis did not demonstrate an alteration at codon 201 (Arg) and 227 (Glu). To our knowledge, this is the first case described in a child of this age.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research