Bovine Spongiform Encephalopathy (BSE) – Mad Cow Disease
Author(s) -
Peter N. Campbell
Publication year - 1998
Publication title -
medical principles and practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 45
eISSN - 1423-0151
pISSN - 1011-7571
DOI - 10.1159/000026039
Subject(s) - bovine spongiform encephalopathy , scrapie , infectious agent , disease , medicine , virology , transmission (telecommunications) , prion protein , kuru , infectious disease (medical specialty) , creutzfeldt jakob syndrome , transmissible spongiform encephalopathy , pathology , electrical engineering , engineering
The background to the epidemic of bovine spongiform encephalopathy (BSE) among cattle in the United Kingdom is described as the possible origin of the disease and its relationship to scrapie in sheep. Although the epidemic in cattle is virtually over there is evidence of the transmission of the infectious agent to humans to produce a new variant of Creutzfeldt-Jakob disease. The current status of our understanding of the molecular biology of the infectious agent is described as is the evidence in support of the protein-only, prion, hypothesis. Study of the glycoforms of the prions supports the view that BSE has been transmitted to humans.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom