Open AccessBlockade of RAS-Binding Domain Interactions Inhibits RAS Signaling
Publication year - 2016
Publication title -
cancer discovery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.795
H-Index - 163
eISSN - 2159-8290
pISSN - 2159-8274
DOI - 10.1158/2159-8290.cd-rw2016-085
Subject(s) - blockade , signal transduction , domain (mathematical analysis) , microbiology and biotechnology , chemistry , pharmacology , computational biology , biology , cancer research , receptor , biochemistry , mathematical analysis , mathematics
Rigosertib acts as a RAS mimetic, binding to the RAS-binding domain of multiple RAS effector proteins.
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