Two Faces of SIVA | Zendy

Lois ResnickSilverman | Zendy; James J. Manfredi | Zendy

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Two Faces of SIVA

Author(s) -

Lois ResnickSilverman,

James J. Manfredi

Publication year - 2015

Publication title -

cancer discovery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.795

H-Index - 163

eISSN - 2159-8290

pISSN - 2159-8274

DOI - 10.1158/2159-8290.cd-15-0484

Subject(s) - kras , cancer research , carcinogenesis , biology , cancer , apoptosis , gene , pi3k/akt/mtor pathway , lung cancer , bioinformatics , medicine , mutation , genetics , oncology

In non-small cell lung cancer cells that contain a mutated KRAS gene, SIVA, a p53 target gene that is critical for apoptosis, is overexpressed in a p53-independent manner and promotes tumorigenesis through the stimulation of mTOR signaling. The ablation of Siva in conditional knockout mice results in an inhibition of tumor development that makes SIVA an interesting new candidate therapeutic target for the treatment of a carcinoma with few therapeutic options.

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