Open AccessHypoxia Signaling—License to Metastasize
Author(s) -
Sakari Vanharanta,
Joan Massagué
Publication year - 2013
Publication title -
cancer discovery
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 6.795
H-Index - 163
eISSN - 2159-8290
pISSN - 2159-8274
DOI - 10.1158/2159-8290.cd-13-0481
Subject(s) - hypoxia (environmental) , cancer research , sarcoma , metastasis , cancer , biology , phenotype , medicine , pathology , chemistry , gene , genetics , organic chemistry , oxygen
Hypoxia-inducible factors (HIF) have long been linked to malignant tumor phenotypes in various cancer types, and several downstream mediators of HIF action are deregulated in metastatic carcinomas. A new study links hypoxia-induced collagen remodeling to sarcoma progression, providing evidence for unifying mechanisms of carcinoma and sarcoma metastasis.
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