Activation of JAK/STAT Signaling in Megakaryocytes Sustains Myeloproliferation In Vivo | Zendy

Brittany A. Woods | Zendy; Wei Chen | Zendy; Sophia Chiu | Zendy; Christian Marinaccio | Zendy; Chunling Fu | Zendy; Lilly Gu | Zendy; Marinka Bulic | Zendy; Qiong Yang | Zendy; Anouar Zouak | Zendy; Shengxian Jia | Zendy; Praveen Suraneni | Zendy; Kailin Xu | Zendy; Ross L. Levine | Zendy; John D. Crispino | Zendy; Qiang Wen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Activation of JAK/STAT Signaling in Megakaryocytes Sustains Myeloproliferation In Vivo

Author(s) -

Brittany A. Woods,

Wei Chen,

Sophia Chiu,

Christian Marinaccio,

Chunling Fu,

Lilly Gu,

Marinka Bulic,

Qiong Yang,

Anouar Zouak,

Shengxian Jia,

Praveen Suraneni,

Kailin Xu,

Ross L. Levine,

John D. Crispino,

Qiang Wen

Publication year - 2019

Publication title -

clinical cancer research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.427

H-Index - 324

eISSN - 1557-3265

pISSN - 1078-0432

DOI - 10.1158/1078-0432.ccr-18-4089

Subject(s) - megakaryocyte , erythropoiesis , thrombocytosis , haematopoiesis , myelofibrosis , polycythemia vera , essential thrombocythemia , biology , cancer research , thrombopoietin , bone marrow , thrombopoietin receptor , megakaryocytopoiesis , ruxolitinib , janus kinase 2 , myeloproliferative disorders , immunology , myeloid , leukocytosis , myelopoiesis , stem cell , signal transduction , medicine , microbiology and biotechnology , platelet , anemia

The myeloproliferative neoplasms (MPN), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are characterized by the expansion of the erythroid, megakaryocytic, and granulocytic lineages. A common feature of these disorders is the presence of abnormal megakaryocytes, which have been implicated as causative agents in the development of bone marrow fibrosis. However, the specific contributions of megakaryocytes to MPN pathogenesis remain unclear.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research