NQO1-dependent, Tumor-selective Radiosensitization of Non–small Cell Lung Cancers | Zendy

Edward A. Motea | Zendy; Xiumei Huang | Zendy; Naveen Singh | Zendy; Jessica A. Kilgore | Zendy; Noelle S. Williams | Zendy; XianJin Xie | Zendy; David E. Gerber | Zendy; Muhammad Shaalan Beg | Zendy; Erik A. Bey | Zendy; David A. Boothman | Zendy

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NQO1-dependent, Tumor-selective Radiosensitization of Non–small Cell Lung Cancers

Author(s) -

Edward A. Motea,

Xiumei Huang,

Naveen Singh,

Jessica A. Kilgore,

Noelle S. Williams,

XianJin Xie,

David E. Gerber,

Muhammad Shaalan Beg,

Erik A. Bey,

David A. Boothman

Publication year - 2019

Publication title -

clinical cancer research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.427

H-Index - 324

eISSN - 1557-3265

pISSN - 1078-0432

DOI - 10.1158/1078-0432.ccr-18-2560

Subject(s) - medicine , in vivo , cancer research , nad+ kinase , pharmacology , in vitro , cancer , carcinogen , chemistry , biology , enzyme , biochemistry , microbiology and biotechnology

Development of tumor-specific therapies for the treatment of recalcitrant non-small cell lung cancers (NSCLC) is urgently needed. Here, we investigated the ability of β-lapachone (β-lap, ARQ761 in clinical form) to selectively potentiate the effects of ionizing radiation (IR, 1-3 Gy) in NSCLCs that overexpress NAD(P)H:Quinone Oxidoreductase 1 (NQO1).

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