Intratumor Heterogeneity in Hepatocellular Carcinoma | Zendy

Juliane Friemel | Zendy; Markus Rechsteiner | Zendy; Lukas Frick | Zendy; Friederike Böhm | Zendy; Kirsten Struckmann | Zendy; Michèle Egger | Zendy; Holger Moch | Zendy; Mathias Heikenwälder | Zendy; Achim Weber | Zendy

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Intratumor Heterogeneity in Hepatocellular Carcinoma

Author(s) -

Juliane Friemel,

Markus Rechsteiner,

Lukas Frick,

Friederike Böhm,

Kirsten Struckmann,

Michèle Egger,

Holger Moch,

Mathias Heikenwälder,

Achim Weber

Publication year - 2014

Publication title -

clinical cancer research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.427

H-Index - 324

eISSN - 1557-3265

pISSN - 1078-0432

DOI - 10.1158/1078-0432.ccr-14-0122

Subject(s) - hepatocellular carcinoma , cytokeratin , immunohistochemistry , pathology , cd44 , sanger sequencing , biology , genetic heterogeneity , liver cancer , carcinoma , cancer , cancer research , cell , medicine , phenotype , gene , mutation , genetics

Morphologic intratumor heterogeneity is well known to exist in hepatocellular carcinoma (HCC), but very few systematic analyses of this phenomenon have been performed. The aim of this study was to comprehensively characterize morphologic intratumor heterogeneity in HCC. Also, taken into account were well-known immunohistochemical markers and molecular changes in liver cells that are considered in proposed classifications of liver cell neoplasms or discussed as molecular therapeutic targets.

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