Clinical Pharmacokinetics of Amifostine and WR1065 in Pediatric Patients with Medulloblastoma | Zendy

Trevor McKibbin | Zendy; John C. Panetta | Zendy; Maryam Fouladi | Zendy; Amar Gajjar | Zendy; Feng Bai | Zendy; M. Fatih Okcu | Zendy; Clinton F. Stewart | Zendy

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Clinical Pharmacokinetics of Amifostine and WR1065 in Pediatric Patients with Medulloblastoma

Author(s) -

Trevor McKibbin,

John C. Panetta,

Maryam Fouladi,

Amar Gajjar,

Feng Bai,

M. Fatih Okcu,

Clinton F. Stewart

Publication year - 2010

Publication title -

clinical cancer research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.427

H-Index - 324

eISSN - 1557-3265

pISSN - 1078-0432

DOI - 10.1158/1078-0432.ccr-09-1997

Subject(s) - amifostine , pharmacokinetics , medicine , population , volume of distribution , pharmacology , bioavailability , urology , chemotherapy , environmental health

We evaluated the pharmacokinetics of amifostine and WR1065 in pediatric patients with newly diagnosed medulloblastoma to assess the influence of patient covariates, including demographics, clinical characteristics, and genetic polymorphisms, on amifostine and WR1065 pharmacokinetic parameters.

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