Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Reverses Mesenchymal to Epithelial Phenotype and Inhibits Metastasis in Inflammatory Breast Cancer | Zendy

Dongwei Zhang | Zendy; Tiffany A. LaFortune | Zendy; Savitri Krishnamurthy | Zendy; Francisco J. Esteva | Zendy; Massimo Cristofanilli | Zendy; Ping Liu | Zendy; Anthony Lucci | Zendy; Balraj Singh | Zendy; MienChie Hung | Zendy; Gabriel N. Hortobágyi | Zendy; Naoto T. Ueno | Zendy

Open Access

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Reverses Mesenchymal to Epithelial Phenotype and Inhibits Metastasis in Inflammatory Breast Cancer

Author(s) -

Dongwei Zhang,

Tiffany A. LaFortune,

Savitri Krishnamurthy,

Francisco J. Esteva,

Massimo Cristofanilli,

Ping Liu,

Anthony Lucci,

Balraj Singh,

MienChie Hung,

Gabriel N. Hortobágyi,

Naoto T. Ueno

Publication year - 2009

Publication title -

clinical cancer research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.427

H-Index - 324

eISSN - 1557-3265

pISSN - 1078-0432

DOI - 10.1158/1078-0432.ccr-09-0951

Subject(s) - cancer research , metastasis , breast cancer , tyrosine kinase , phenotype , tyrosine kinase inhibitor , inflammatory breast cancer , epidermal growth factor receptor , cancer , medicine , mesenchymal stem cell , receptor tyrosine kinase , biology , receptor , pathology , gene , biochemistry

Inflammatory breast cancer (IBC) is a rare but aggressive type of advanced breast cancer. Epidermal growth factor receptor (EGFR) expression is an independent poor prognostic factor in IBC. The purpose of this study was to determine the effect on IBC tumorigenicity and metastasis of blocking the EGFR pathway.

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