Open AccessAKT/mTOR Pathway Activation and BCL-2 Family Proteins Modulate the Sensitivity of Human Small Cell Lung Cancer Cells to RAD001
Author(s) -
Marin Marinov,
Algirdas Ziogas,
Olivier E. Pardo,
Liwen Terence Tan,
Tony Dhillon,
Francesco Mauri,
Heidi A. Lane,
Nicholas R. Lemoine,
Uwe ZangemeisterWittke,
Michael J. Seckl,
Alexandre Arcaro
Publication year - 2009
Publication title -
clinical cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.427
H-Index - 324
eISSN - 1557-3265
pISSN - 1078-0432
DOI - 10.1158/1078-0432.ccr-08-2166
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , cancer research , rptor , biology , everolimus , cell growth , cell culture , signal transduction , microbiology and biotechnology , biochemistry , genetics
The Akt/mammalian target of rapamycin (mTOR) pathway is frequently activated in human cancers and plays an important role in small cell lung cancer (SCLC) biology. We investigated the potential of targeting mTOR signaling as a novel antitumor approach in SCLC.