Open AccessCytosolic Phospholipase A2-α: A Potential Therapeutic Target for Prostate Cancer
Author(s) -
Manish I. Patel,
Jaskirat Singh,
Marzieh Niknami,
Caroline Kurek,
Yuguang Mu,
Sasa Lu,
Fiona Maclean,
Nicholas J. C. King,
Michael H. Gelb,
Kieran F. Scott,
Pamela J. Russell,
John Boulas,
Qihan Dong
Publication year - 2008
Publication title -
clinical cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.427
H-Index - 324
eISSN - 1557-3265
pISSN - 1078-0432
DOI - 10.1158/1078-0432.ccr-08-0566
Subject(s) - prostate cancer , cancer research , small interfering rna , lncap , prostate , cyclin d1 , phospholipase a2 , biology , cancer cell , cancer , medicine , endocrinology , cell culture , cell cycle , transfection , biochemistry , genetics , enzyme
Cytosolic phospholipase A2-alpha (cPLA2-alpha) provides intracellular arachidonic acid to supply both cyclooxygenase and lipoxygenase pathways. We aim to determine the expression and activation of cPLA2-alpha in prostate cancer cell lines and tissue and the effect of targeting cPLA2-alpha in vitro and in vivo.