Open AccessMorin (3,5,7,2′,4′-Pentahydroxyflavone) Abolishes Nuclear Factor-κB Activation Induced by Various Carcinogens and Inflammatory Stimuli, Leading to Suppression of Nuclear Factor-κB–Regulated Gene Expression and Up-regulation of Apoptosis
Author(s) -
Sunil K. Manna,
Rishi S. Aggarwal,
Gautam Sethi,
Bharat B. Aggarwal,
Govindarajan T. Ramesh
Publication year - 2007
Publication title -
clinical cancer research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.427
H-Index - 324
eISSN - 1557-3265
pISSN - 1078-0432
DOI - 10.1158/1078-0432.ccr-06-2394
Subject(s) - morin , carcinogen , gene expression , chemistry , microbiology and biotechnology , biology , gene , cancer research , biochemistry , medicine , pathology
Morin is a flavone that exhibits antiproliferative, antitumor, and anti-inflammatory effects through a mechanism that is not well understood. Because of the role of transcription factor nuclear factor-kappaB (NF-kappaB) in the control of cell survival, proliferation, tumorigenesis, and inflammation, we postulated that morin mediates its effects by modulating NF-kappaB activation.