Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia | Zendy

Juhi Ojha | Zendy; Veryan Codd | Zendy; Christopher P. Nelson | Zendy; Nilesh J. Samani | Zendy; Ivan Smirnov | Zendy; Nils R. Madsen | Zendy; Helen M. Hansen | Zendy; Adam J. de Smith | Zendy; Paige M. Bracci | Zendy; John K. Wiencke | Zendy; Margaret Wrensch | Zendy; Joseph L. Wiemels | Zendy; Kyle M. Walsh | Zendy

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Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia

Author(s) -

Juhi Ojha,

Veryan Codd,

Christopher P. Nelson,

Nilesh J. Samani,

Ivan Smirnov,

Nils R. Madsen,

Helen M. Hansen,

Adam J. de Smith,

Paige M. Bracci,

John K. Wiencke,

Margaret Wrensch,

Joseph L. Wiemels,

Kyle M. Walsh

Publication year - 2016

Publication title -

cancer epidemiology biomarkers and prevention

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.234

H-Index - 192

eISSN - 1538-7755

pISSN - 1055-9965

DOI - 10.1158/1055-9965.epi-15-1329

Subject(s) - chronic lymphocytic leukemia , telomere , single nucleotide polymorphism , germline , leukemia , case control study , genome wide association study , biology , medicine , genetics , immunology , oncology , genotype , gene

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. Shorter mean telomere length in leukemic cells has been associated with more aggressive disease. Germline polymorphisms in telomere maintenance genes affect telomere length and may contribute to CLL susceptibility.

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