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Common Breast Cancer Susceptibility Variants inLSP1andRAD51L1Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk
Author(s) -
Celine M. Vachon,
Christopher G. Scott,
Peter A. Fasching,
Per Hall,
Rulla M. Tamimi,
Jingmei Li,
Jennifer Stone,
Carmel Apicella,
Fabrice Odefrey,
Gretchen L. Gierach,
Sebastian M. Jud,
Katharina Heusinger,
Matthias W. Beckmann,
Marina Pollán,
Pablo FernándezNavarro,
Anna GonzálezNeira,
Javier Benı́tez,
Carla H. van Gils,
Mariëtte Lokate,
N. Charlotte OnlandMoret,
Petra H. Peeters,
Judith K. Brown,
Jean Leyland,
Jajini S. Varghese,
Douglas F. Easton,
Deborah J. Thompson,
Robert Luben,
Ruth Warren,
Nicholas J. Wareham,
Ruth J. F. Loos,
KayTee Khaw,
Giske Ursin,
Eunjung Lee,
Simon A. Gayther,
Susan J. Ramus,
Rosalind A. Eeles,
Martin O. Leach,
Gek Kwan-Lim,
Fergus J. Couch,
Graham G. Giles,
Laura Baglietto,
Kavitha Krishnan,
Melissa C. Southey,
Loı̈c Le Marchand,
Laurence N. Kolonel,
Christy Woolcott,
Gertraud Maskarinec,
Christopher A. Haiman,
Kate Walker,
Nichola Johnson,
Valerie McCormack,
Margarethe Biong,
Grethe I.G. Alnæs,
Inger Torhild Gram,
Vessela N. Kristensen,
AnneLise BørresenDale,
Sara Lindström,
Susan E. Hankinson,
David J. Hunter,
Irene L. Andrulis,
Julia A. Knight,
Norman F. Boyd,
Jonine D. Figuero,
Jolanta Lissowska,
Ewa Wesołowska,
Beata Pepłońska,
Agnieszka Bukowska,
Edyta Reszka,
Jianjun Liu,
Louise Eriksson,
Kamila Czene,
Tina Audley,
Anna H. Wu,
V. Shane Pankratz,
John L. Hopper,
Isabel dosSantosSilva
Publication year - 2012
Publication title -
cancer epidemiology biomarkers and prevention
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.234
H-Index - 192
eISSN - 1538-7755
pISSN - 1055-9965
DOI - 10.1158/1055-9965.epi-12-0066
Subject(s) - breast cancer , mammographic density , medicine , mammography , body mass index , cancer , oncology , genetic predisposition , risk factors for breast cancer , disease
Mammographic density adjusted for age and body mass index (BMI) is a heritable marker of breast cancer susceptibility. Little is known about the biologic mechanisms underlying the association between mammographic density and breast cancer risk. We examined whether common low-penetrance breast cancer susceptibility variants contribute to interindividual differences in mammographic density measures.

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