Meeting Report: The Role of the Mobilome in Cancer | Zendy

Daniel Ardeljan | Zendy; Martin S. Taylor | Zendy; Kathleen H. Burns | Zendy; Jef D. Boeke | Zendy; Michael Graham Espey | Zendy; Elisa C. Woodhouse | Zendy; T. Kevin Howcroft | Zendy

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Meeting Report: The Role of the Mobilome in Cancer

Author(s) -

Daniel Ardeljan,

Martin S. Taylor,

Kathleen H. Burns,

Jef D. Boeke,

Michael Graham Espey,

Elisa C. Woodhouse,

T. Kevin Howcroft

Publication year - 2016

Publication title -

cancer research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.103

H-Index - 449

eISSN - 1538-7445

pISSN - 0008-5472

DOI - 10.1158/0008-5472.can-15-3421

Subject(s) - transposable element , biology , derepression , cancer , genetics , piwi interacting rna , mobile genetic elements , endogenous retrovirus , computational biology , human genome , genome , gene , gene expression , psychological repression

Approximately half of the human genome consists of repetitive sequence attributed to the activities of mobile DNAs, including DNA transposons, RNA transposons, and endogenous retroviruses. Of these, only long interspersed elements (LINE-1 or L1) and sequences copied by LINE-1 remain mobile in our species today. Although cells restrict L1 activity by both transcriptional and posttranscriptional mechanisms, L1 derepression occurs in developmental and pathologic contexts, including many types of cancers. However, we have limited knowledge of the extent and consequences of L1 expression in premalignancies and cancer. Participants in this NIH strategic workshop considered key questions to enhance our understanding of mechanisms and roles the mobilome may play in cancer biology. Cancer Res; 76(15); 4316-9. ©2016 AACR.

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