Effect of mosapride on capsule endoscopy: A systematic review of randomized controlled trials

AIM: To assess the effect of mosapride on capsule endoscopy. METHODS: We searched Cochrane Central Register of Controlled Trails(CENTRAL), MEDLINE or PubMed, and Chinese VIP database. The bibliographies of retrieved articles and correlated proceedings were also searched manually. A systematic review was conducted using the method recommended by the Cochrane Collaboration. RESULTS: Seven trials involving 500 patients were included in the systematic review. Metaanalysis showed that mosapride was superior to the blank control in terms of gastric emptying time(P < 0.00001), small-bowel transit time(P < 0.00001) and the completion rate of small bowel examination(P < 0.00001); however, mosapridewas not superior to the blank control in the diagnostic yield(P = 0.05). CONCLUSION: The limited current evidence shows that mosapride decreases gastric emptying time and improves the completion rate of total small-bowel examination in patients undergoing capsule endoscopy. However, all these findings should be interpreted with caution and more clinical trials are needed.