Open AccessInhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha
Author(s) -
W.K. Seow,
Kazuhiro Nakamura,
Yukio Sugimura,
Yukihiro Sugimoto,
Yasuyuki Yamada,
David P. Fairlie,
Y.H. Thong
Publication year - 1993
Publication title -
mediators of inflammation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.37
H-Index - 97
eISSN - 1466-1861
pISSN - 0962-9351
DOI - 10.1155/s0962935193000262
Subject(s) - tumor necrosis factor alpha , pathogenesis , immunology , proinflammatory cytokine , interleukin , benzylisoquinoline , medicine , cytokine , alpha (finance) , pharmacology , inflammation , chemistry , biochemistry , enzyme , biosynthesis , surgery , construct validity , patient satisfaction
Synthesis of IL-1beta and TNFalpha by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC(50) values in the muM range. The results indicate that these compounds may have value in the therapy of human diseases where these inflammatory cytokines have a central role in pathogenesis.
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