Strains of Rodents and the Pharmacology of Learning and Memory | Zendy

Martine AmmassariTeule | Zendy; Claudio Castellano | Zendy

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Strains of Rodents and the Pharmacology of Learning and Memory

Author(s) -

Martine AmmassariTeule,

Claudio Castellano

Publication year - 2004

Publication title -

neural plasticity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.288

H-Index - 68

eISSN - 2090-5904

pISSN - 1687-5443

DOI - 10.1155/np.2004.205

Subject(s) - mendelian inheritance , neuroscience , selection (genetic algorithm) , pharmacogenetics , psychology , biology , computational biology , cognitive science , computer science , machine learning , gene , genetics , genotype

Mendelian genetic tools have extensively been used to improve the description of the pharmacological mechanisms involved in learning and memory. The first part of this short review describes experiments involving the bidirectional selection of rats or mice for extreme behavioral characteristics or for sensitivity to pharmacological treatments. The second part focuses specifically on in-breeding. In conclusion, the advantages and the limits of a Mendelian pharmacogenetic approach of learning and memory are discussed.

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