Long‐Term Recording of LTP in Cultured Hippocampal Slices | Zendy

Ken Shimono | Zendy; Michel Baudry | Zendy; Lam T. Ho | Zendy; Makoto Taketani | Zendy; Gary Lynch | Zendy

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Long‐Term Recording of LTP in Cultured Hippocampal Slices

Author(s) -

Ken Shimono,

Michel Baudry,

Lam T. Ho,

Makoto Taketani,

Gary Lynch

Publication year - 2002

Publication title -

neural plasticity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.288

H-Index - 68

eISSN - 2090-5904

pISSN - 1687-5443

DOI - 10.1155/np.2002.249

Subject(s) - long term potentiation , hippocampal formation , neuroscience , term (time) , hippocampus , chemistry , computer science , biology , medicine , physics , receptor , quantum mechanics

Long-term potentiation (LTP) was elicited by high frequency stimulation in hippocampal slices cultured on multi-electrode arrays. LTP lasting more than 1 h was recorded in 75% of slices, and a significant number of slices exhibited a non-decaying LTP that lasted more than 48 h. LTP induction was completely and reversibly blocked by an antagonist of the NMDA receptor, APV. Our results suggest the possibility of using chronic recording in hippocampal slices cultured on multi-electrode arrays to study the mechanisms underlying LTP maintenance and stabilization.

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