Nerve Growth Factor with Insular Cortical Grafts Induces Recovery of Learning and Reestablishes Graft Choline Acetyltransferase Activity | Zendy

Martha L. Escobar | Zendy; N. Jiménez | Zendy; Juan Carlos López | Zendy; Ricardo Tapia | Zendy; Federico BermúdezRattoni | Zendy

Open Access

Nerve Growth Factor with Insular Cortical Grafts Induces Recovery of Learning and Reestablishes Graft Choline Acetyltransferase Activity

Author(s) -

Martha L. Escobar,

N. Jiménez,

Juan Carlos López,

Ricardo Tapia,

Federico BermúdezRattoni

Publication year - 1993

Publication title -

neural plasticity

Language(s) - English

Resource type - Journals

eISSN - 2090-5904

pISSN - 1687-5443

DOI - 10.1155/np.1993.167

Subject(s) - choline acetyltransferase , nerve growth factor , insular cortex , glutamate decarboxylase , taste aversion , choline , medicine , cortex (anatomy) , endocrinology , taste , psychology , neuroscience , chemistry , central nervous system , enzyme , receptor , biochemistry

Rats showing disrupted taste aversion due to insular cortex (IC)-lesions received either IC-grafts with NGF, grafts without NGF, or NGF alone. An additional group served as lesioned controls. Only those animals that received IC-grafts with NGF recovered the ability to learn the conditioned taste aversion task, at 15 days post-graft. Choline acetyltransferase (ChAT) activity in the IC-grafts with, but not without NGF, was similar to the IC activity of unoperated controls. In contrast, glutamate decarboxylase activity was similar in all the groups. These findings suggest that IC-grafts associated with NGF induce recovery of learning abilities in IC-lesioned rats, which correlates with reestablishment of ChAT activity in the grafts at 15 days post-implantation.

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