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Serotonin Axons Lose the Ability to Grow Into Fetal Ventral Mesencephalic Grafts Shortly After Birth
Author(s) -
Guy Doucet,
Abderrahman Mounir,
Meriem Chkirate,
Annie Vallée,
M. Geffard
Publication year - 1992
Publication title -
neural plasticity
Language(s) - English
Resource type - Journals
eISSN - 2090-5904
pISSN - 1687-5443
DOI - 10.1155/np.1992.219
Subject(s) - serotonin , midbrain , fetus , neuroscience , medicine , anatomy , biology , pregnancy , central nervous system , genetics , receptor
Adult host serotonin (5-HT) neurons display a particularly good capacity to innervate intrastriatal grafts of fetal tissue from several CNS regions /1,2/. However, following intra-striatal transplantation of ventral mesencephalic tissue, the 5-HT innervation from adult host brain was found to be very sparse and almost exclusively confined to the borders of the grafts /3/. The present study investigated whether neonatal 5-HT neurons would show a better potential than adult ones for axonal growth into such grafts. Unilateral implantation of dis

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