Functional Heterogeneity of the Striatum in a Rodent Model of Huntington′s Disease: Considerations for Neurological Transplantation | Zendy

E. E. Concepcion | Zendy; Walter C. Low | Zendy

Open Access

Functional Heterogeneity of the Striatum in a Rodent Model of Huntington′s Disease: Considerations for Neurological Transplantation

Author(s) -

E. E. Concepcion,

Walter C. Low

Publication year - 1992

Publication title -

neural plasticity

Language(s) - English

Resource type - Journals

eISSN - 2090-5904

pISSN - 1687-5443

DOI - 10.1155/np.1992.185

Subject(s) - striatum , rodent model , huntington's disease , neuroscience , transplantation , rodent , disease , medicine , psychology , biology , dopamine , ecology

Recent studies utilizing a neurotoxic model of Huntington's disease (HD) in rodents have demonstrated locomotor abnormalities following unilateral lesions of the striatum. The behavioral abnormalities are manifested as an asymmetric rotation ipsilateral to the side of the lesion following apomorphine administration. The current study provides evidence for the dependence of rotational direction on the site of the striatal lesion and suggests factors for consideration in utilizing similar models in future neural transplantation research.

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