Open AccessInvestigation of Midtrimester Amniotic Fluid Factors as Potential Predictors of Term and Preterm Deliveries
Author(s) -
Ariadne MalamitsiPuchner,
Nikolaos Vrachnis,
Evi Samoli,
Stavroula Baka,
George Alexandrakis,
Karl-Philipp Puchner,
Zoi Iliodromiti,
Demetrios Hassiakos
Publication year - 2006
Publication title -
mediators of inflammation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.37
H-Index - 97
eISSN - 1466-1861
pISSN - 0962-9351
DOI - 10.1155/mi/2006/94381
Subject(s) - amniotic fluid , medicine , elastase , gestational age , premature rupture of membranes , slpi , preterm labor , obstetrics , asymptomatic , intercellular adhesion molecule 1 , pregnancy , pulmonary surfactant , andrology , inflammation , gestation , fetus , chemistry , biology , enzyme , biochemistry , genetics
Aims. Our aim is to investigate, in 13 cases (delivering preterm) and 21 matched (for age, parity, and gestational age) controls (delivering at term), whether midtrimester amniotic fluid concentrations of elastase, secretory leukocyte proteinase inhibitor (SLPI), soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule predict asymptomatic intra-amniotic inflammation/infection and preterm labor. Results. Concentrations of all substances were not statistically different among mothers, delivering preterm or at term. SLPI concentrations significantly increased in women, going into labor without ruptured membranes, irrespective of pre- or term delivery (P<.007, P<.001, resp) and correlated withelastase (r=0.508, P<.002). Conclusions. Midtrimester amniotic fluid SLPI concentrations significantly decrease when membrane rupture precedes pre- or full-term labor. However, none of the investigated substances predict preterm delivery
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