Interleukin‐1 Modulation of Human Placental Trophoblast Proliferation | Zendy

Athip Nilkaeo | Zendy; Suthinee Bhuvanath | Zendy

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Interleukin‐1 Modulation of Human Placental Trophoblast Proliferation

Author(s) -

Athip Nilkaeo,

Suthinee Bhuvanath

Publication year - 2006

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1155/mi/2006/79359

Subject(s) - trophoblast , mifepristone , decidua , choriocarcinoma , cell growth , cell cycle , biology , apoptosis , microbiology and biotechnology , receptor , cell cycle checkpoint , cell culture , andrology , cancer research , placenta , pregnancy , medicine , fetus , biochemistry , genetics

During early pregnancy, interleukin-1 (IL-1) is mainly produced and secreted by maternal decidua. Yet, its biological function on placental cells is not well defined. In this study, we employed JAR choriocarcinoma cell line as a model of human placental trophoblast to study the effect of IL-1. Treatment with recombinant human IL-1 β resulted in significant inhibition of JAR proliferation ( P<.05 ) paralleled with increased cytotoxicity. The inhibitory effect was blocked by both IL-1 receptor antagonist (IL-1Ra) and antihuman IL-1 β monoclonal antibody. Analyzing the mode of action, IL-1 β was found to induce cell cycle arrest in the G0/G1 phase and triggered apoptotic cell death. These findings demonstrated that IL-1 regulates human trophoblast growth by induction of cell cycle delay and cell death.