Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1 | Zendy

Eric F. Morand | Zendy; Pam Hall | Zendy; Paul Hutchinson | Zendy; Yuan Yang | Zendy

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Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1

Author(s) -

Eric F. Morand,

Pam Hall,

Paul Hutchinson,

Yuan Yang

Publication year - 2006

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1155/mi/2006/73835

Subject(s) - annexin a1 , annexin a2 , annexin , downregulation and upregulation , glucocorticoid , messenger rna , annexin a5 , dexamethasone , chemistry , endocrinology , biology , medicine , microbiology and biotechnology , flow cytometry , biochemistry , gene

The glucocorticoid (GC)-induced antiinflammatory molecule annexin I is expressed in leukocytes and has antiinflammatory effects in animal models of arthritis, but the expression of annexin I in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) is unknown. We report the constitutive and dexamethasone (DEX)-inducible expression of annexin I in RA FLS. DEX increased FLS annexin I protein translocation and mRNA expression. Interleukin (IL)-1 β also induced annexin I translocation and mRNA but also increased intracellular protein. DEX and IL-1 had additive effects on annexin I mRNA, but DEX inhibited the inducing effect of IL-1 β on cell surface annexin I. These results indicate that glucocorticoids and IL-1 β upregulate the synthesis and translocation of annexin I in RA FLS, but interdependent signalling pathways are involved.