Open AccessTumor Necrosis Factor‐α in Temporomandibular Joint Synovial Fluid Predicts Treatment Effects on Pain by Intra‐Articular Glucocorticoid Treatment
Author(s) -
Lars Fredriksson,
Per Alstergren,
Sigvard Kopp
Publication year - 2006
Publication title -
mediators of inflammation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.37
H-Index - 97
eISSN - 1466-1861
pISSN - 0962-9351
DOI - 10.1155/mi/2006/59425
Subject(s) - temporomandibular joint , synovial fluid , medicine , tumor necrosis factor alpha , glucocorticoid , alpha (finance) , pathology , surgery , osteoarthritis , construct validity , alternative medicine , patient satisfaction
The aim of this study was to investigate the influence of tumor necrosis factor-α (TNF-α) in temporomandibular joint (TMJ) synovial fluid and blood on the treatment effect on TMJ pain by intra-articular injection of glucocorticoid in patients with chronic inflammatory TMJ disorders. High pretreatment level of TNF-α in the synovial fluid was associated with a decrease of TNF-α and elimination of pain upon maximal mouth opening. Elimination of this TMJ pain was accordingly associated with decrease in synovial fluid level of TNF-α. There was also a significant decrease of C-reactive protein and TMJ resting pain after treatment. In conclusion, this study indicates that presence of TNF-α in the synovial fluid predicts a treatment effect of intra-articular injection of glucocorticoid on TMJ movement pain in patients with chronic TMJ inflammatory disorders
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