Modification of Interleukin‐15 Serum Levels in Workers Exposed to Chemotherapeutic Agents | Zendy

Giovanna Spatari | Zendy; Concettina Fenga | Zendy; Paola Lucia Minciullo | Zendy; Giuseppe Di Pasquale | Zendy; Anna Cacciola | Zendy; Elvira Ventura-Spagnolo | Zendy; Sebastiano Gangemi | Zendy

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Modification of Interleukin‐15 Serum Levels in Workers Exposed to Chemotherapeutic Agents

Author(s) -

Giovanna Spatari,

Concettina Fenga,

Paola Lucia Minciullo,

Giuseppe Di Pasquale,

Anna Cacciola,

Elvira Ventura-Spagnolo,

Sebastiano Gangemi

Publication year - 2005

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1155/mi.2005.60

Subject(s) - medicine , in vivo , cancer , interleukin , carcinogen , occupational exposure , chemotherapeutic drugs , interleukin 6 , chemotherapy , colorectal cancer , immunology , pharmacology , oncology , inflammation , biology , cytokine , environmental health , microbiology and biotechnology , genetics

Cytostatic anticancer drugs are known as carcinogenic, mutagenic, and teratogenic risk factors for health care workers occupationally exposed. It has been demonstrated that the administration of interleukin-15 in rat models of colon carcinoma protects against chemotherapy-induced gastrointestinal toxicities. We found that occupational exposure to chemotherapeutic antiblastic agents in vivo modified circulating levels of interleukin-15 in 17 health care workers exposed to antineoplastic drugs in relation to their jobs and in as many healthy age- and sex-matched subjects. Health care workers displayed significantly higher circulating interleukin-15 levels compared to their age-matched controls. If this increase representing an anticancer response remains to be established, these findings strengthen the idea of a therapeutic use of interleukin-15 in the field of cancer.

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