Neurotrophin‐3 and FLT3 Tyrosine Kinase Receptor in Perinatal Life | Zendy

Ariadne MalamitsiPuchner | Zendy; Emmanouel Economou | Zendy; Τheodora Boutsikou | Zendy; Konstantin Nikolaou | Zendy; Nikolaos Vrachnis | Zendy

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Neurotrophin‐3 and FLT3 Tyrosine Kinase Receptor in Perinatal Life

Author(s) -

Ariadne MalamitsiPuchner,

Emmanouel Economou,

Τheodora Boutsikou,

Konstantin Nikolaou,

Nikolaos Vrachnis

Publication year - 2005

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1155/mi.2005.53

Subject(s) - fetus , neurotrophin , tyrosine kinase , medicine , endocrinology , central nervous system , tropomyosin receptor kinase c , receptor , receptor tyrosine kinase , pregnancy , biology , platelet derived growth factor receptor , growth factor , genetics

Our aim is to determine--in 30 healthy full-term infants and their mothers--circulating levels of neurotrophin-3 (NT-3) (important for antenatal and postnatal brain development and implicated in the immune response) and FLT3 tyrosine kinase receptor (FLT3) (controlling hematopoiesis and found in the nervous tissue), in the fetal and neonatal life. NT-3 levels, in contrast to FLT3 ones, increased significantly on the fourth postnatal day in relation to the low levels found in the mother, fetus, and day 1 neonate (P = .03, respectively). Maternal and umbilical NT3 levels positively correlated with respective FLT3 levels (P = .003 and P = .03). Circulating NT-3 levels increased in early neonatal life, possibly due to exposure to various stimuli soon after birth. FLT3 levels do not seem to behave accordingly, although these two substances probably synergize.

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