Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis | Zendy

Lars Fredriksson | Zendy; Per Alstergren | Zendy; Sigvard Kopp | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis

Author(s) -

Lars Fredriksson,

Per Alstergren,

Sigvard Kopp

Publication year - 2005

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1155/mi.2005.194

Subject(s) - serotonergic , glucocorticoid , medicine , arthritis , neuroscience , bioinformatics , serotonin , biology , receptor

The aims of this study were to investigate the influence of serotonin (5-HT) on the effects of intra-articular injections of glucocorticoid on pain of the temporomandibular joint (TMJ) in patients with inflammatory disorders of the TMJ. The pretreatment synovial fluid 5-HT was negatively, and plasma 5-HT positively, correlated to change in TMJ pain after treatment. The pretreatment plasma 5-HT was positively correlated to change in pressure-pain threshold after treatment. In conclusion, this study shows that local and systemic serotonergic mechanisms partly determine the effect of intra-articular glucocorticoid treatment on TMJ pain in patients with chronic TMJ arthritis of systemic nature, while change in pressure-pain threshold over the TMJ is influenced by systemic serotonergic mechanisms.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research