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Proinflammatory mediators are important in the pathogenesis of IBD, which are regulated by activation of NF-kappaB. The aim of this study was to investigate whether melatonin reduces inflammatory injury and inhibits proinflammatory molecule and NF-kappaB in rats with colitis. Rat colitis model was established by TNBS enema. NF-kappaB p65, TNF-alpha, ICAM-1, and IkappaBalpha in colon tissue were examined by immunohistochemistry, EMSA, RT-PCR, and Western blot analysis. Expression of proinflammatory molecule and activation of NF-kappaB were upregulated and IkappaB level decreased in rats with colitis. Melatonin reduces colonic inflammatory injury through downregulating proinflammatory molecule mediated by NF-kappaB inhibition and blockade of IkappaBalpha degradation.

mediators of inflammation

Melatonin Reduces Inflammatory Injury through Inhibiting NF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="$\kappa$" id="E1"><mml:mi>κ</mml:mi></mml:math>B Activation in Rats with Colitis

Melatonin Reduces Inflammatory Injury through Inhibiting NF-κB Activation in Rats with Colitis