On the Role of sIL‐2R Measurements in Rheumatoid Arthritis and Cancers | Zendy

Anna Maria Witkowska | Zendy

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On the Role of sIL‐2R Measurements in Rheumatoid Arthritis and Cancers

Author(s) -

Anna Maria Witkowska

Publication year - 2005

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1155/mi.2005.121

Subject(s) - rheumatoid arthritis , medicine , cancer research , arthritis , immunology , oncology

A soluble IL-2 receptor (sIL-2R) is a circulating form of a membrane receptor localized on lymphoid and some cancer cells. The biological function of sIL-2R has not been completely understood. Substantially, it seems to reflect T-lymphocyte activation in diseases of different pathology. Moreover, the soluble receptor has been considered, at least in part, responsible for unsuccessful immunotherapy with IL-2 in cancers. Several lines of evidence indicate sIL-2R measurements to be useful in determining disease progress and prognosis. This review summarizes current knowledge on the sIL-2R behavior in RA and solid cancers of varied etiology.

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