Facile Synthesis of cis‐Dichloro‐(1,4,7‐Triazacyclononane) Platinum(II) and its Screening Against Human Ovarian Cancer (SK‐OV‐3) and Leukemia (K‐562) Cell Lines | Zendy

Robert I. Haines | Zendy; Aleisha M. Murnaghan | Zendy

Open Access

Facile Synthesis of cis‐Dichloro‐(1,4,7‐Triazacyclononane) Platinum(II) and its Screening Against Human Ovarian Cancer (SK‐OV‐3) and Leukemia (K‐562) Cell Lines

Author(s) -

Robert I. Haines,

Aleisha M. Murnaghan

Publication year - 2002

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.2002.61

Subject(s) - ovarian cancer , platinum , cancer research , leukemia , cancer cell lines , cell culture , cancer , chemistry , combinatorial chemistry , oncology , cancer cell , medicine , biology , biochemistry , genetics , catalysis

A simple method for the preparation of cis-dichloro(1,4,7-triazacyclononane)platinum(II), cis-Pt(tacn)Cl(2) is presented, together with the results of screening the compound against the K-562 (leukemia) and SK-OV-3 (ovarian) human cancer cell lines. While the compound shows no activity against K-562 cells, there is evidence for some cytotoxicity against SK-OV-3. The compound is much less effective than cisplatin, and its limited solubility restricts the useable concentration range.

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