Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides | Zendy

E. Lukevics | Zendy; Э. Абеле | Zendy; Pavel Arsenyan | Zendy; Р. Абеле | Zendy; Кира Рубина | Zendy; Irīna Shestakova | Zendy; Илона Домрачева | Zendy; Violetta Vologdina | Zendy

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Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides

Author(s) -

E. Lukevics,

Э. Абеле,

Pavel Arsenyan,

Р. Абеле,

Кира Рубина,

Irīna Shestakova,

Илона Домрачева,

Violetta Vologdina

Publication year - 2002

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.2002.45

Subject(s) - quinoline , cytotoxicity , pyridine , silicon , chemistry , combinatorial chemistry , organic chemistry , biochemistry , in vitro

Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S-[3-(1-methyl- 1-silacyclohexyl)propyl] derivatives 5e and 6e exhibit the highest cytotoxicity. Aliphatic silicon derivatives were considerably less active. 8-[(Trimethylsilylmethyl)thio]quinoline (8a) exhibits the highest activity among quinoline sulfides.

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