Biologically Active Co(II) and Ni(II) Complexes ofN‐(2‐Thienylmethylene)‐2‐Aminothiadiazole | Zendy

Zahid H. Chohan | Zendy

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Biologically Active Co(II) and Ni(II) Complexes ofN‐(2‐Thienylmethylene)‐2‐Aminothiadiazole

Author(s) -

Zahid H. Chohan

Publication year - 2002

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.2002.323

Subject(s) - schiff base , chemistry , chelation , octahedron , escherichia coli , stereochemistry , metal , antibacterial activity , staphylococcus aureus , octahedral molecular geometry , medicinal chemistry , bacteria , nuclear chemistry , ion , inorganic chemistry , biochemistry , organic chemistry , biology , genetics , gene

Co(II) and Ni(II) complexes Schiff base, N-(2-thienylmethylene)-2-aminothiadiazole have been prepared and characterized by their physical, spectral and analytical data. The title Schiff-base acts as NNS donor tridentate during the complexation reaction with these metal ions having a composition, [M(L)(2)]X(n) where M=Co(II) or Ni(II), L=, X=NO(3) (-), SO(4) (2-), C(2)O(4) (2-) or CH(3)CO(2) (-) and n=1 or 2 and show an octahedral geometry. In order to evaluate the effect anions upon chelation, the Schiff-base and its new complexes have been screened for their antibacterial activity against bacterial strains e.g., Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.

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