Antibacterial Co(II) and Ni(II) Complexes ofN‐(2‐Furanylmethylene)‐2‐Aminothiadiazole and Role of SO42−,NO3−, C2O42− and CH3CO2− anions on Biological Properties | Zendy

Zahid H. Chohan | Zendy; Abdur Rauf | Zendy; Claudiu T. Supuran | Zendy

Open Access

Antibacterial Co(II) and Ni(II) Complexes ofN‐(2‐Furanylmethylene)‐2‐Aminothiadiazole and Role of SO42−,NO3−, C2O42− and CH3CO2− anions on Biological Properties

Author(s) -

Zahid H. Chohan,

Abdur Rauf,

Claudiu T. Supuran

Publication year - 2002

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.2002.287

Subject(s) - schiff base , escherichia coli , chelation , chemistry , metal ions in aqueous solution , octahedron , metal , octahedral molecular geometry , staphylococcus aureus , antibacterial activity , base (topology) , stereochemistry , medicinal chemistry , ion , bacteria , nuclear chemistry , inorganic chemistry , biochemistry , biology , organic chemistry , mathematics , genetics , gene , mathematical analysis

Co(II) and Ni(II) complexes with a Schiff base, N-(2-furanylmethylene)-2-aminothiadiazole have been prepared and characterized by their physical, spectral and analytical data. The synthesized Schiff-bases act as tridentate ligands during the complexation reaction with Co(II) and Ni(II. metal ions. They possess the composition [M(L)(2)]X(n) (where M=Co(II) or Ni(II), L=, X=NO(3) (-), SO(4) (2-), C(2)O(4) (2-) or CH(3)CO(2) (-) and n=1 or 2) and show an octahedral geometry. In order to evaluate the effect of anions upon chelation, the Schiff-base and its complexes have been screened for antibacterial activity against bacterial strains e.g., Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.

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