Antifungal Activity of Solventlessly Synthesized Organomercurials | Zendy

Mazaahir Kidwai | Zendy; R. Venkataramanan | Zendy; B. Dave | Zendy

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Antifungal Activity of Solventlessly Synthesized Organomercurials

Author(s) -

Mazaahir Kidwai,

R. Venkataramanan,

B. Dave

Publication year - 2002

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.2002.283

Subject(s) - antifungal , yield (engineering) , chemistry , pyrimidine , solvent , nuclear chemistry , microwave irradiation , chloride , combinatorial chemistry , organic chemistry , organic solvent , stereochemistry , catalysis , materials science , microbiology and biotechnology , biology , chemical engineering , metallurgy , engineering

A series of new barbituryl/thiobarbituryl substituted organomercurial derivatives 3a-i have been synthesised from pyrimidine derivatives 1a-c and arylmercuric chloride 2a-c over K(2)CO(3) under microwave irradiations (MWI). This solventless synthesis apart from eliminating organic solvent from workup step, also gave improved yield as compared to the conventional heating, with reaction time reduced from hours to minutes. The prepared compounds were tested against A. niger and A. flavous for their antifungal activity and were found to posses good activity.

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