Cerebroprotective Effects of Dimeric Copper(II)Bis(o‐acetoxybenzoate) on Ischemia‐reperfusion Injury in Gerbils | Zendy

Ling Li | Zendy; Shen Zhi-qiang | Zendy; Weimin Yang | Zendy; Wanling Wu | Zendy; Weiping Liu | Zendy; Zhihe Chen | Zendy

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Cerebroprotective Effects of Dimeric Copper(II)Bis(o‐acetoxybenzoate) on Ischemia‐reperfusion Injury in Gerbils

Author(s) -

Ling Li,

Shen Zhi-qiang,

Weimin Yang,

Wanling Wu,

Weiping Liu,

Zhihe Chen

Publication year - 2002

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.2002.253

Subject(s) - ischemia , reperfusion injury , copper , chemistry , pharmacology , anesthesia , medicine , organic chemistry

The cerebroprotective effects of copper aspirinate [dimeric copper(II) bis(o-acetoxybenzoate)] were investigated in gerbils subjected to 10-min global cerebral ischemia followed b 60-min reperfusion. The results showed that intragastric copper aspirinate (7.5, 15.0 and 30.0 mg Kg(-1)) markedly promoted the recovery of the electroencephalogram amplitude, attenuated the increase of lipid peroxide content and the decrease of superoxide dismutase activity in the cortex during ischemia-reperfusion injury. It suggested that copper aspirinate possesses potential neuroprotective properties, the mechanism of which might be related to an increase of the activity of endogenous superoxide dismutase.

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