Apoptosis Induced by Metal Complexes and Interaction with Dexamethasone | Zendy

Jung Sun Kim | Zendy; José Carlos Almeida Barros | Zendy; Szulim Ber Zyngier | Zendy

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Apoptosis Induced by Metal Complexes and Interaction with Dexamethasone

Author(s) -

Jung Sun Kim,

José Carlos Almeida Barros,

Szulim Ber Zyngier

Publication year - 2002

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.2002.249

Subject(s) - jurkat cells , apoptosis , raji cell , hl60 , cell culture , agarose gel electrophoresis , chemistry , microbiology and biotechnology , flow cytometry , biology , cell , t cell , biochemistry , immunology , immune system , genetics , gene

Apoptosis induced by rhodium II amidate, rhodium II propionate, cisplatin and interactions with dexamethaxone were studied on some human leukemia cell lines Raji, Jurkat and U937. Apoptosis was studied by flow cytometry, agarose gel electrophoresis and morphological analysis. Rhodium II propionate induced apoptosis in all the three cell lines, Rhodium II amidate, in the lymphoid cell lines Jurkat and Raji, and cisplatin, only in the Jurkat, a T lymphoid cell line. It has also been observed that the addition of dexamethasone enhances the apoptosis index only in U937, a monocytic line with a glucocorticoid receptor bearing.

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