Synthesis of Silicon and Germanium Containing Heteroaromatic Sulfides as Cholesterol Level Lowering and Vasodilating Agents | Zendy

Кира Рубина | Zendy; Э. Абеле | Zendy; Pavel Arsenyan | Zendy; Р. Абеле | Zendy; Māris Vēveris | Zendy; E. Lukevics | Zendy

Open Access

Synthesis of Silicon and Germanium Containing Heteroaromatic Sulfides as Cholesterol Level Lowering and Vasodilating Agents

Author(s) -

Кира Рубина,

Э. Абеле,

Pavel Arsenyan,

Р. Абеле,

Māris Vēveris,

E. Lukevics

Publication year - 2001

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.2001.85

Subject(s) - benzothiazole , germanium , thio , silicon , chemistry , silylation , alkyl , thiol , catalysis , toluene , halide , organic chemistry , medicinal chemistry

Silicon and germanium containing heteroaromatic sulfides have been prepared using phase transfer catalytic (PTC) system thiol / Si or Ge containing alkyl halide / solid KOH / 18- crown-6 / toluene. The target sulfides were isolated in yields up to 92 %. It has been found that 2-{[dimethyl (beta-triethylgermylethyl)-silylmethyl]thio}-1-methylimidazole and 2-{[dimethyl(beta-triphenylsilylethyl) silyl-methyl]thio}benzothiazole are the most active cholesterol level lowering and vasodilating agents.

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