Open AccessCytotoxicity of Triorganophosphinegold(I) Complexes of Thiobenzoate
Author(s) -
Beverly R. Vincent,
David J. Clarke,
Douglas R. Smyth,
Dick de Vos,
Edward R. T. Tiekink
Publication year - 2001
Publication title -
metal-based drugs
Language(s) - English
Resource type - Journals
ISSN - 0793-0291
DOI - 10.1155/mbd.2001.79
Subject(s) - cytotoxicity , chemistry , stereochemistry , in vitro , biochemistry
The preparation and characterization of two triorganophosphinegold(I) complexes containing the anion derived from thiobenzoic acid are described. The cytotoxicity of these complexes has been investigated along with that of triphenylphosphinegold(I) mercaptopurinate, a known anti-tumor compound, against a variety of human cell lines. The complexes showed moderate to high cytotoxicity (ID(50) 250 - 2500 ng/ml).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom